Immunotherapy of guinea pigs with dermal and visceral tumor implants: comparison of living and nonliving BCG.
نویسندگان
چکیده
Emulsified cell walls of Mycobacterium bovis (BCG) were immunotherapeutically at least as active as living BCG in prolonging survival of guinea pigs with established dermal tumors and microscopic lymph node and visceral metastases.
منابع مشابه
Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs.
Guinea pigs, each with an established, syngeneic dermal tumor (line-10) and microscopic lymph node metastasis, were treated by intradermal inoculation of living line-10 tumor cells admixed with emulsified heat-killed Mycobacterium bovis BCG cells. This treatment caused complete regression of established dermal tumors (about 10 mm in diameter) and prevented the growth of microscopic lymph node m...
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Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose displayed a stronger tumor regressive activity and the process of healing was accelerated when endotoxin from a rough (Re) strain of Salmonella typhimurium was added to the BCG bacilli.
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Heat-killed whole BCG cells (KC) and BCG cell walls (CW) were each tested in emulsified form for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basis, KC were at least as effective as CW in causing tumor regression and elimination of microscopic lymph node metastasis, and they, as well as purified protein derivative of mycobacteria, provoked delayed cutaneo...
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We studied the conditions required for eradication by immunization of occult lymph node metastases which remained after surgical removal of an intradermally transplanted cavian hepatoma. Guinea pigs that received no postsurgical treatment all died with progressively growing lymph node metastases. The growth of these metastases could be prevented in a significant proportion of the animals by pos...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 24 2 شماره
صفحات -
تاریخ انتشار 1979